DOI: https://doi.org/10.15574/SP.2019.97.49

Виром человека

D. S. Yankovsky, G. S. Dyment, V. V. Berezhnoy, V. O. Kitam, N. V. Khimich

Аннотация


Обзор посвящен изучению вирусного компонента микробиома человека — вирома. Приведены современные данные, касающиеся состава вирома, его формирования в процессе онтогенеза, роли в патогенезе болезней или поддержании гомеостаза. Особое внимание уделено бактериофагам (фагобиому) как доминантному члену вирома. Представлены сведения о влиянии бактериофагов на состояние прокариотного сообщества микробиома, иммунную систему и их потенциальное участие в развитии патологии. Рассмотрены дискуссионные вопросы, касающиеся перспектив использования бактериофаговой терапии в медицине.

Ключевые слова


виром; микробиом; вирусы; бактериофаги; метагеномика; прокариоты; фагобиом; фаговая терапия

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Литература


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