Фармакология витамина D

Авторы

  • I.S. Chekman Киевский медицинский университет Украинской ассоциации народной медицины; Национальный медицинский университет имени А.А. Богомольца; Национальная медицинская академия последипломного образования имени П.Л. Шупика, Ukraine
  • N.A. Gorchakova Киевский медицинский университет Украинской ассоциации народной медицины; Национальный медицинский университет имени А.А. Богомольца; Национальная медицинская академия последипломного образования имени П.Л. Шупика, Ukraine
  • V.V. Berezhniy Киевский медицинский университет Украинской ассоциации народной медицины; Национальный медицинский университет имени А.А. Богомольца; Национальная медицинская академия последипломного образования имени П.Л. Шупика, Ukraine
  • A.V. Davydiuk Киевский медицинский университет Украинской ассоциации народной медицины; Национальный медицинский университет имени А.А. Богомольца; Национальная медицинская академия последипломного образования имени П.Л. Шупика, Ukraine
  • M.R. Roman'ko Киевский медицинский университет Украинской ассоциации народной медицины; Национальный медицинский университет имени А.А. Богомольца; Национальная медицинская академия последипломного образования имени П.Л. Шупика, Ukraine

DOI:

https://doi.org/10.15574/SP.2017.82.28

Ключевые слова:

витамин D, метаболизм, гиповитаминоз, профилактика, лечение

Аннотация

В обзорной статье показаны пути поступления и роль витамина D в организме человека. В настоящее время дефицит витамина D охватывает большую часть человеческой популяции. Для коррекции гиповитаминоза D применяют препараты, которые на рынке Украины представлены в форме масляного и водного растворов витамина D, а также в виде витамин D-содержащих витаминных комплексов.

Библиографические ссылки

Abaturov AE, Zavgorodnyaya NYu. 2012. Vitamin-D-zavisimaya produktsiya antimikrobnyih peptidov. Zdorovia dytyny. 1(36): 20—21.

Hanzhyi IIu. 2013. Kliniko-patohenetychne obgruntuvannia profilaktyky ta likuvannia syndromu polikistoznykh yaiechnykiv u zhinok riznykh vikovykh hrup. Avtoref dys … kand med nauk. DU «Instytut pediatrii, akusherstva i hinekolohii NAMN Ukrainy». Kyiv: 36.

Kvashnina LV. 2013. Imunomoduliuiuchi efekty vitaminu D u ditei. Zdorovia dytyny. 7.

Komisarenko YuI. 2013. Vitamin D ta yoho rol u rehuliatsii metabolichnykh rozladiv. Lektsii, ohliady, novyny. 4: 51—54.

Maydannik VG. 2014. Klinicheskie rekomendatsii po diagnostike, lecheniyu i profilaktike vitamin D-defitsitnogo rahita u detey. Kiev: 58.

Tatarchuk TF, Zadorozhnaya TD, Kapshuk IN et al. 2015. Morfologicheskie osobennosti yaichnikov kryis pri eksperimentalnom D3 gipovitaminoze. Zdorove zhenschinyi. 1(97): 195-198.

Semin SG, Volkova LV, Moiseev AB, Nikitina NV. 2012. Perspektivyi izucheniya biologicheskoy roli vitamina D. Pediatriya Zhurnal im GN Speranskogo. 91(2): 122—131.

Povorozniuk VV, Balatska NI. 2013. Defitsyt vitaminu D u naselennia Ukrainy ta chynnyky ryzyku yoho rozvytku. Reprodukt endokrynol. 5(13): 7—13.

Povoroznyuk VV. 2013. Sostoyanie problemyi osteoporoza i drugih metabolicheskih zabolevaniy skeleta v Ukraine. Nov med farmats. 3(487): 10—13.

Shvarts GYa. 2009. Vitamin D, D-gormon i alfakaltsidiol: meditsinskie, molekulyarno-biologicheskie i farmakologicheskie aspektyi. Ukr revmatol zhurn. 3: 63—69

Gysemans CA, Cardozo AK, Callewaert H et al. 2005. 1.25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in non-obese diabetic mice. Endocrinology. 146(4): 1956—1964. https://doi.org/10.1210/en.2004-1322; PMid:15637289

Cardus A, Panizo S, Encinas M et al. 2009. 1.25-dihydroxyvitamin D3 regulates VEGF production through a vitamin D response element in the VEGF promoter. Atherosclerosis. 204(1): 85—89. https://doi.org/10.1016/j.atherosclerosis.2008.08.020; PMid:18834982

Soderstrom LH, Johnson SP, Diaz VA, Mainous AG. 2012. 3-d. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001—2004 NHANES. Diabet Med. 29(1): 50—55. https://doi.org/10.1111/j.1464-5491.2011.03379.x; PMid:21726279 PMCid:PMC3461835

Nimptsch K, Platz EA, Willett WC, Giovannucci E. 2012. Association between plasma 25-OH vitamin D and testosterone levels in men. Clin Endocrinol (Oxf). 77(1): 106—112. https://doi.org/10.1111/j.1365-2265.2012.04332.x; PMid:22220644 PMCid:PMC3712348

Lee HS, Kim YJ, Shim YS et al. 2014. Associations between serum vitamin D levels and precocious puberty in girls. Ann Pediatr Endocrinol Metab. 19(2): 91—95. https://doi.org/10.6065/apem.2014.19.2.91; PMid:25077092 PMCid:PMC4114046

Forouhi NG, Luan J et al. 2008. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes. 57: 2619—2625. https://doi.org/10.2337/db08-0593; PMid:18591391 PMCid:PMC2551670

Bikle D. 2009. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 94: 26—34. https://doi.org/10.1210/jc.2008-1454; PMid:18854395 PMCid:PMC2630868

Billaudel BJ, Faure AG, Sutter BC. 1990. Effect of 1,25dihydroxyvitamin D3 on isolated islets from vitamin D3-deprived rats. Am J Physiol. 258; 4 Pt 1: 643—648.

Bodnar LM, Krohn MA, Simhan HN. 2009. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr. 139(6): 1157—1161. https://doi.org/10.3945/jn.108.103168; PMid:19357214 PMCid:PMC2682987

Brock KE, Huang WY. 2011. Diabetes prevalence is associatedwith serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Br J Nutr. 106(3): 339—344. https://doi.org/10.1017/S0007114511001590; PMid:21736838 PMCid:PMC3515777

Sooy K, Schermerhorn T, Noda M et al. 1999. Calbindin-D (28k) controls [Ca(2+)](i) and insulin release. Evidence obtained from calbindin-D(28k) knockout mice and beta cell lines. J Biol Chem. 274(48): 34343—34349. https://doi.org/10.1074/jbc.274.48.34343; PMid:10567411

Castro LC. 2011. The vitamin D endocrine system. Arq Bras Endocrinol Metabol. 55(8): 566-575. https://doi.org/10.1590/S0004-27302011000800010; PMid:22218438

Maghbooli Z, Hossein-Nezhad A, Karimi F et al. 2008. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev. 24(1): 27—32. https://doi.org/10.1002/dmrr.737; PMid:17607661

Wortsman J, Matsuoka LY, Chen TC et al. 2000. Decreased bioavailability of vitamin D in obesity. Amer J Clin Nutr. 72: 690—693. PMid:10966885

Sheth JJ, Shah A, Sheth FJ et al. 2015. Does vitamin D play a significant role in type 2 diabetes? BMC Endocr Disord. 15: 5. https://doi.org/10.1186/s12902-015-0003-8; PMid:25887335 PMCid:PMC4357062

Evans KN, Nguyen L, Chan J et al. 2006. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol Reprod. 75(6): 816-822. https://doi.org/10.1095/biolreprod.106.054056; PMid:16957024

Holick MF, Binkley NC, Bischoff-Ferrari HA et al. 2011. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 96(7): 1911—1930. https://doi.org/10.1210/jc.2011-0385; PMid:21646368

Bischoff-Ferrari HA, Giovannucci E, Willett WC. 2006. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 84(1): 18-28. PMid:16825677

Chen TC, Chimeh F, Lu Z et al. 2007. Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys. 460(2): 213—217. https://doi.org/10.1016/j.abb.2006.12.017; PMid:17254541 PMCid:PMC2698590

Baker AM, Haeri S, Camargo CA et al. 2011. First-trimester maternal vitamin D status and risk for gestational diabetes (GDM) a nested case-control study. Diabetes Metab Res Rev. 28(2): 164-168. https://doi.org/10.1002/dmrr.1282; PMid:21818838 PMCid:PMC4381548

Forouhi NG, Ye Z. 2012. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia. 55(8): 2173—2182. https://doi.org/10.1007/s00125-012-2544-y; PMid:22526608

Saraf R, Morton SM, Camargo CAJr, Grant CC. 2015, Sep 15. Global summary of maternal and newborn vitamin D status — a systematic review. Matern Child Nutr. Epub ahead of print. PMid:26373311

Grundmann M, von Versen-Hoynck F. 2011. Vitamin D-roles in women's reproductive health? Reprod Biol Endocrinol. 9: 146. https://doi.org/10.1186/1477-7827-9-146; PMid:22047005 PMCid:PMC3239848

Heaney RP. 2008. Vitamin D in health and disease. Clin J Am Soc Nephrol. 3(5): 1535—1541. https://doi.org/10.2215/CJN.01160308; PMid:18525006 PMCid:PMC4571146

Holick MF. 2007. Vitamin D deficiency. N Engl J Med. 357(3): 266—281. https://doi.org/10.1056/NEJMra070553; PMid:17634462

Maestro B, Da’vila N, Carranza MC, Calle C. 2003. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Molecul Biol. 84: 223-230. https://doi.org/10.1016/S0960-0760(03)00032-3

Donoso MA, Munoz-Calvo MT, Barrios V et al. 2009. Increased circulating adiponectin levels and decreased leptin/soluble leptin receptor ratio throughout puberty in female ballet dancers: association with body composition and the delay in puberty. Eur J Endocrinol. 162(5): 905—911. https://doi.org/10.1530/EJE-09-0874; PMid:20145046

Ranjzad F, Mahban A, Shemirani AI et al. 2011. Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. J Assist Reprod Genet. 28(3): 225—232. https://doi.org/10.1007/s10815-010-9506-4; PMid:21082232 PMCid:PMC3082662

Dawson-Hughes B, Mithal A, Bonjour JP et al. 2010. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 21(7): 1151—1154. https://doi.org/10.1007/s00198-010-1285-3; PMid:20422154

Jones G. 2008. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. 88: 582—586.

Ju SY, Jeong HS, do Kim H. 2014. Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis. J Clin Endocrinol Metab. 99(3): 1053-1063. https://doi.org/10.1210/jc.2013-3577; PMid:24423309

Kamycheva ER, Joakimsen M, Jorde R. 2003. Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. J Nutr. 133: 102—106. PMid:12514276

Hahn S, Haselhorst U, Tan S et al. 2006. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exper Clin Endocrinol Diab. 114: 577—583. https://doi.org/10.1055/s-2006-948308; PMid:17177140

Mathieu C, Gysemans C. 2006. Vitamin D and diabetes. Av Diabetol. 22(3): 187—193.

Mithal A. 2014. Treatment of vitamin D deficiency. Endocrine case management ICE/ENDO 2014 Meet-the professor, Endocrine society: 37—39.

Morris HA, Anderson PH. 2010. Autocrine and paracrine actions of vitamin D. Clin Biochem Rev. 31(4): 129—138. PMid:21170259 PMCid:PMC2998276

Pittas AG, Sun Q, Manson JE. 2010. Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care. 33(9): 2021—2023. https://doi.org/10.2337/dc10-0790; PMid:20805275 PMCid:PMC2928356

Gomez de Tejada Romero MJ, Sosa Henriquez M, Del Pino Montes J et al. 2011. Position document on the requirements and optimum levels of vitamin D. Rev Osteoporos Metab Miner. 1: 53—64.

Ozkan S, Jindal S, Greenseid K et al. 2009. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 94(4): 1314—1319. https://doi.org/10.1016/j.fertnstert.2009.05.019; PMid:19589516 PMCid:PMC2888852

Thomson RL, Spedding S, Brinkworth GD et al. 2013. Seasonal effects on vitamin D status influence outcomes of lifestyle intervention in overweight and obese women with polycystic ovary syndrome. Fertil Steril. 99(6): 1779—1785. https://doi.org/10.1016/j.fertnstert.2012.12.042; PMid:23357457

Lau SL, Gunton JE, Athayde NP et al. 2013. Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus. Med J Aust. 194(7): 334—337.

Shipton EE, Shipton EA. 2015. Vitamin D deficite and pain. Pain Ther. 4(1): 67—87. https://doi.org/10.1007/s40122-015-0036-8; PMid:25920326 PMCid:PMC4470966

Shoelson SE, Herrero L, Naaz A. 2007. Obesity, inflammation, and insulin resistance. Gastroenterol. 132: 2169—2180. https://doi.org/10.1053/j.gastro.2007.03.059; PMid:17498510

Smolikova K, Mlynarcikova A, Scsukova S. 2013. Effect of 1α,25-dihydroxyvitamin D3 on progesterone secretion by porcine ovarian granulosa cells. Endocr Regul. 47(3): 123—131. https://doi.org/10.4149/endo_2013_03_123; PMid:23889482

Rashidi B, Haghollahi F, Shariat M, Zayerii F. 2011. The effects of calcium — vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwan J Obstet Gynecol. 48(2): 142—147. https://doi.org/10.1016/S1028-4559(09)60275-8

Procopio M, Magro G, Cesario F et al. 2002. The oral glucose tolerance test reveals a high frequency of both impaired glucose tolerance and undiagnosed Type 2 diabetes mellitus in primary hyperparathyroidism. Diabet Med. 19: 958—961. https://doi.org/10.1046/j.1464-5491.2002.00809.x; PMid:12421435

Krul-Poel YH, Snackey C, Louwers Y et al. 2013. The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. Eur J Endocrinol. 169(6): 853-865. https://doi.org/10.1530/EJE-13-0617; PMid:24044903

Khoo AL, Chai L, Koenen H et al. 2012. Translating the role of vitamin D3 in infectious diseases. Crit Rev Microbiol. 38(2): 122—135. https://doi.org/10.3109/1040841X.2011.622716; PMid:22304022

Liu NQ, Kaplan AT, Lagishetty V et al. 2011. Vitamin D and the regulation of placental inflammation. J Immunol. 186(10): 5968—5974. https://doi.org/10.4049/jimmunol.1003332; PMid:21482732

Gilbert-Diamond D, Baylin A, Mora-Plazas M et al. 2010. Vitamin D deficiency and anthropometric indicators of adiposity in school — age children: a prospective studyю Am J Clin Nutr. 92(6): 1446—1451. https://doi.org/10.3945/ajcn.2010.29746; PMid:20926524 PMCid:PMC3131841

Bischoff-Ferrari HA, Burckhardt P, Quack-Loetscher K et al. 2012. Vitamin D deficiency: Evidence, safety, and recommendations for the Swiss population. Report written by a group of experts on behalf of the Federal Commission for Nutrition (FCN). PMCid:PMC3319875

Pludowski P, Holick MF, Pilz S et al. 2013. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality — a review of recent evidence. Autoimmun Rev. 12(10): 976—989. https://doi.org/10.1016/j.autrev.2013.02.004; PMid:23542507

Compston JE, Vedi S, Ledger JE et al. 1981. Vitamin D status and bone histomorphometry in gross obesity. Amer J Clinical Nutr. 34: 2359—2363. PMid:7304477

Hollis BW, Johnson D, Hulsey TC et al. 2011. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 26(10): 2341—2357. https://doi.org/10.1002/jbmr.463; PMid:21706518 PMCid:PMC3183324

Reis JP, von Muhlen D, Kritz-Silverstein D et al. 2007. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care. 30(6): 1549—1555. https://doi.org/10.2337/dc06-2438; PMid:17351276

Christakos S, Dhawan P, Benn B et al. 2007. Vitamin D: molecular mechanism of action. Ann N Y Acad Sci. 1116: 340—348. https://doi.org/10.1196/annals.1402.070; PMid:18083936

Wehr E, Trummer O, Giuliani A et al. 2011. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol. 164(5): 741—749. https://doi.org/10.1530/EJE-11-0134; PMid:21389086

Wehr E, Pieber TR, Obermayer-Pietsch B. 2011. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J Endocrinol Invest. 34(10): 757—763. PMid:21613813

Опубликован

2017-04-05

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