Аллельные полиморфизмы С-590Т гена IL4 и С-159Т гена CD14 как вероятные генетические маркеры повышенной склонности к развитию повторных эпизодов острого обструктивного бронхита у детей
DOI:
https://doi.org/10.15574/SP.2016.80.129Ключевые слова:
острые респираторные заболевания, дети, молекулярно-генетический анализ, повторные эпизоды острого обструктивного бронхита, полиморфизм геновАннотация
Цель: поиск молекулярно-генетических маркеров повышенной склонности детей к повторным эпизодам острого обструктивного бронхита (ООБ).
Пациенты и методы. Обследован 31 ребенок в возрасте от 2 до 8 лет с частыми острыми респираторными заболеваниями, которые осложнялись повторными эпизодами ООБ. Группу контроля составили 35 детей аналогичного возраста, болевших острым бронхитом не чаще 1–2 раз в год. Результаты молекулярно-генетического исследования сравнивали с данными 50 человек, отобранных методом случайной выборки, которые вошли в общепопуляционную контрольную группу.
Результаты. Доказано, что наличие в генотипе ребенка полиморфного локуса C-590T гена IL4 в 3 раза увеличивает риск повторных эпизодов ООБ. Не зарегистрирована достоверно более высокая частота генотипов СС, СТ и ТТ полиморфного локуса С-159Т гена CD14.
Выводы. С целью прогнозирования у детей генетически детерминированной склонности к повторным эпизодам ООБ рекомендуется проведение молекулярно-генетического тестирования генотипов СТ и СС полиморфного локуса C-590T гена IL4.
Ключевые слова: острые респираторные заболевания, дети, молекулярно-генетический анализ, повторные эпизоды острого обструктивного бронхита, полиморфизм генов.
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