Аллельные полиморфизмы С-590Т гена IL4 и С-159Т гена CD14 как вероятные генетические маркеры повышенной склонности к развитию повторных эпизодов острого обструктивного бронхита у детей

O. Kens, G. Akopyan, N. Lukyanenko, V. Bergtravm

Аннотация


Цель: поиск молекулярно-генетических маркеров повышенной склонности детей к повторным эпизодам острого обструктивного бронхита (ООБ).


Пациенты и методы.
Обследован 31 ребенок в возрасте от 2 до 8 лет с частыми острыми респираторными заболеваниями, которые осложнялись повторными эпизодами ООБ. Группу контроля составили 35 детей аналогичного возраста, болевших острым бронхитом не чаще 1–2 раз в год. Результаты молекулярно-генетического исследования сравнивали с данными 50 человек, отобранных методом случайной выборки, которые вошли в общепопуляционную контрольную группу.


Результаты.
Доказано, что наличие в генотипе ребенка полиморфного локуса C-590T гена IL4 в 3 раза увеличивает риск повторных эпизодов ООБ. Не зарегистрирована достоверно более высокая частота генотипов СС, СТ и ТТ полиморфного локуса С-159Т гена CD14.


Выводы.
С целью прогнозирования у детей генетически детерминированной склонности к повторным эпизодам ООБ рекомендуется проведение молекулярно-генетического тестирования генотипов СТ и СС полиморфного локуса C-590T гена IL4.


Ключевые слова:
острые респираторные заболевания, дети, молекулярно-генетический анализ, повторные эпизоды острого обструктивного бронхита, полиморфизм генов.


Ключевые слова


острые респираторные заболевания; дети; молекулярно-генетический анализ; повторные эпизоды острого обструктивного бронхита; полиморфизм генов

Полный текст:

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Литература


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DOI: https://doi.org/10.15574/SP.2016.80.129

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