Развитие иммунного ответа при пневмококковой пневмонии. Часть 3
DOI:
https://doi.org/10.15574/SP.2016.78.60Ключевые слова:
пневмококковая пневмония, клеточные реакции, фагоцитоз, Th1 и Th17-ассоциированный иммунный ответ, антипневмококковые антителаАннотация
В статье показан неспецифический (фагоцитоз) и специфический Th1-, Th17-ассоциированный иммунный ответ при инфицировании Streptococcus pneumoniae. Дана характеристика фенотипов макрофагов респираторного тракта в инициации бактериального киллинга за счет генерации активных азотсодержащих метаболитов и нейтрофилов, обладающих протеолитической активностью за счет катепсина G, нейтрофильной эластазы и протеиназы 3. Продемонстрирована основная роль Th17-клеток в процессе саногенеза пневмококковой инфекции. Секретируемый данными клетками IL-17A рекрутирует профессиональные фагоциты (нейтрофилы или макрофаги) в регион колонизации, обуславливая подавление роста колонии Streptococcus pneumoniae. Th17-клетки памяти играют ключевую роль в обеспечении защиты от Streptococcus pneumoniae серотип-независимым способом, а расширение спектра действия антипневмококковых вакцин может быть основано на разработке методов активации Th17-клеток.
Ключевые слова: пневмококковая пневмония, клеточные реакции, фагоцитоз, Th1 и Th17-ассоциированный иммунный ответ, антипневмококковые антитела.
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