DOI: https://doi.org/10.15574/SP.2016.77.54

Развитие иммунного ответа при пневмококковой пневмонии. Часть 2

A. E. Abaturov, Е. А. Agafonova, A. A. Nikulina

Аннотация


Статья посвящена изучению роли различных цитокинов (IL-1β, IL-6, IL-8, IL-10, IL-17, TNF-α, интерферонов I и II типов) в развитии воспалительного процесса при пневмококковой пневмонии. Представлена характеристика семейств интерлейкинов, хемокинов, интерферонов, участвующих в формировании адекватного воспалительного процесса и неспецифического иммунного ответа, направленного на элиминацию Streptococcus pneumoniae. Показано активное участие интерфероновой системы в антибактериальной защите (в рекогниции, процессинге, презентации антигена, трансдукции внутриклеточного сигнала, активации факторов транскрипции, продукции цитокинов).

Ключевые слова: пневмококковая пневмония, иммунный ответ, цитокины, интерфероны.


Ключевые слова


пневмококковая пневмония; иммунный ответ; цитокины; интерфероны

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Литература


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