Развитие иммунного ответа при пневмококковой пневмонии (часть 1)
DOI:
https://doi.org/10.15574/SP.2016.76.47Ключевые слова:
пневмония, Streptococcus pneumoniae, дети, иммунный ответ, PRR, инфламмасомаАннотация
В статье представлена роль пневмококковой инфекции в структуре острых бактериально ассоциированных заболеваний респираторного тракта у детей и механизмы формирования иммунного ответа, направленные на эрадикацию внеклеточного возбудителя. На основании анализа литературных источников дано современное представление о функционировании молекулярних механизмов рекогниции пневмококковых патоген-ассоциированных молекулярных структур и индукции внутриклеточных сигнальных путей возбуждения эффекторных клеток респіраторного тракта. Продемонстрировано, что для инициации воспалительного процесса при пневмококковой инфекции необходимо, как минимум, два сигнала, один из которых активирует образ-распознающие рецепторы, а второй обуславливает формирование и активацию инфламмасомы.
Ключевые слова: пневмония, Streptococcus pneumoniae, дети, иммунный ответ, PRR, инфламмасома.
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