Первичные дефициты антителообразования: современные подходы к диагностике и лечению
DOI:
https://doi.org/10.15574/SP.2015.70.102Ключевые слова:
первичные дефициты антителообразования, диагностика, лечениеАннотация
Первичные дефициты антителообразования — самая большая группа первичных иммунодефицитов. Эта гетерогенная клинически и генетически группа врожденных дефектов иммунной системы включает легкие, нередко бессимптомные, дефициты IgA и субклассов IgG и тяжелые агаммаглобулинемии с угнетением продукции всех классов антител. Частые клинические проявления — тяжелые или рецидивирующие синопульмонарные инфекции. Возможно развитие аутоиммунной патологии, энтеропатий. Заместительная терапия препаратами иммуноглобулинов — основной метод лечения гипогаммаглобулинемий.
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