Toll-подобные рецепторы: роль врожденного иммунитета в патогенезе преждевременных родов и механизмах повреждения центральной нервной системы у недоношенных детей

Авторы

  • O. S. Yablon
  • D. Y. Vlasenko

DOI:

https://doi.org/10.15574/55112

Аннотация

Представлен современный взгляд на строение, механизмы функционирования и биологическое значение Toll-подобных рецепторов. Особое внимание уделено роли рецепторов врожденного иммунитета в патофизиологии преждевременных родов и освещению патогенетических механизмов повреждения тканей центральной нервной системы у недоношенных детей. 

Ключевые слова: Toll-подобные рецепторы, врожденный иммунитет, воспаление, преждевременные роды, недоношенные дети, повреждение ЦНС. 

Библиографические ссылки

Abaturov AE, Volosovets AP, Yulish EI. 2012. Retseptornyie mehanizmyi vospalitelnogo protsessa pri infektsionnyih zabolevaniyah. Zdorove rebenka. 4(39): 138—141.

Abaturov AE, Volosovets AP, Yulish EI. 2012. Rol TOLL-podobnyih retseptorov v rekognitsii patogen-assotsiirovannyih molekulyarnih struktur infektsionnyih patogennyih agentov i razvitii vospaleniya. Chast 1. Semeystvo TLR. Zdorove rebenka. 5(40): 116—121.

Abaturov AE, Volosovets AP, Yulish EI. 2012. Rol TOLL-podobnyih retseptorov v rekognitsii patogen-assotsiirovannyih molekulyarnih struktur infektsionnyih patogennyih agentov i razvitii vospaleniya. Chast 2. Ligandyi TLR. Zdorove rebenka. 6(41): 213—219.

Abaturov AE, Volosovets AP, Yulish EI. 2012. Rol TOLL-podobnyih retseptorov v rekognitsii patogen-assotsiirovannyih molekulyarnih struktur infektsionnyih patogennyih agentov i razvitii vospaleniya. Chast 3. Rekognitsiya ligandov TLR. Zdorove rebenka. 7(42): 157—164.

Abaturov AE, Volosovets AP, Yulish EI. 2012. Rol TOLL-podobnyih retseptorov v rekognitsii patogen-assotsiirovannyih molekulyarnih struktur infektsionnyih patogennyih agentov i razvitii vospaleniya. Chast 4. Vnurikletochnyie signalnyie puti TLR. Zdorove rebenka. 8(43): 163—168.

Horinets IB. 2010. Rol zapalnykh reaktsii u rozvytku vnutrishnoshlunochkovykh krovovylyviv u hlybokonedonoshenykh novonarodzhenykh. PAH. 5: 7—13.

Osypchuk DV, Dons’koi BV, Chernyshov VP. 2014. Activation of toll-like receptors in systemic immune response. Perinatologiya i pediatriya. 1(57): 68—71.

Rakhmankulova ZZh. 2010. Kliniko-imunolohichni paraleli pry poiednanykh vnutrishnoutrobnykh infektsiiakh u novonarodzhenykh. PAH. 5: 24—27.

Tolstopyatova MA, Buslaeva GA, Kozlov IG. 2008. Rol retseptorov vrozhdennogo immuniteta v razvitii infektsionnoy patologii u novorozhdennyih detey. Pediatriya. 87;1: 115—120.

Elovitz MA, Wang Z, Chien EK et al. 2003. A New Model for Inflammation-Induced Preterm Birth. The Role of Platelet-Activating Factor and Toll-Like Receptor-4. Am J Pathol. 163(5): 2103—2111. http://dx.doi.org/10.1016/S0002-9440(10)63567-5

Burl S, Townend J, Njie-Jobe J et al. 2011 Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants. PLoS One. 6(4): 181—185. http://dx.doi.org/10.1371/journal.pone.0018185; PMid:21533209 PMCid:PMC3076452

Berger I, Peleg O, Ofek-Shlomai N. 2012. Inflammation and Early Brain Injury in Term and Preterm Infants. IMAJ. 14: 815—827.

Bowie A, O'Neill AJ. 2000. The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. Journal of Leukocyte Biology. 67: 508—514. PMid:10770283

Von Ehrenstein OS, Neta GI, Andrews W et al. 2012. Child Intellectual Development in Relation to Cytokine Levels in Umbilical Cord Blood. Am J Epidemiol. 175(11): 1191—1199. http://dx.doi.org/10.1093/aje/kwr393; PMid:22508393 PMCid:PMC3370884

Pappas A, Kendrick DE, Shankaran S et al. 2014. Chorioamnionitis and early childhood outcomes among extremely low-gestational-age neonates. JAMA Pediatr. 168(2): 137—147. http://dx.doi.org/10.1001/jamapediatrics.2013.4248; PMid:24378638 PMCid:PMC4219500

Carlo WA, McDonald SA, Tyson JE et al. 2012. Cytokines and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants. J Pediatr. 159(6): 919—925. http://dx.doi.org/10.1016/j.jpeds.2011.05.042; PMid:21798559 PMCid:PMC3215787

Romero R, Chaiworapongsa T, Savasan ZA et al. 2011. Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1. J Matern Fetal Neonatal Med. 24(12): 1444—1455. http://dx.doi.org/10.3109/14767058.2011.591460; PMid:21958433 PMCid:PMC3419589

Wynn JL, Scumpia PhO, Winfield RD et al. 2008. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood. 112(5): 1750—1758. http://dx.doi.org/10.1182/blood-2008-01-130500; PMid:18591384 PMCid:PMC2518883

Brochu M-E, Girard S, Lavoie K et al. 2011. Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. J Neuroinflammation. 8: 55. http://dx.doi.org/10.1186/1742-2094-8-55; PMid:21599903 PMCid:PMC3121616

Douglas-Escobar M, Weiss MD. 2012. Biomarkers of Brain Injury in the Premature Infant. Front Neurol. 3: 185. PMid:23346073 PMCid:PMC3551194

Galic MA, Riazi K, Pittman QJ. 2013. Cytokines and brain excitability. Front Neuroendocrinol. 33(1): 116—125. http://dx.doi.org/10.1016/j.yfrne.2011.12.002; PMid:22214786 PMCid:PMC3547977

Sadeghi K, Berger A, Langgartner M et al. 2007. Immaturity of Infection Control in Preterm and Term Newborns Is Associated with Impaired Toll-Like Receptor Signaling. JID. 195: 296-302. http://dx.doi.org/10.1086/509892; PMid:17191175

Lavoie PM, Ladd M, Hirschfeld AF et al. 2012. Influence of Common Non-Synonymous Toll-like Receptor 4 Polymorphisms on Bronchopulmonary Dysplasia and Prematurity in Human Infants. PLoS One. 7(2): 313—351. http://dx.doi.org/10.1371/journal.pone.0031351; PMid:22348075 PMCid:PMC3279371

Kollmann TR, Levy O, Montgomery RR et al. 2012. Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly. Immunity. 37: 341—348. http://dx.doi.org/10.1016/j.immuni.2012.10.014; PMid:23159225 PMCid:PMC3538030

Krumbiegel D, Zepp F, Meyer CU. 2007. Combined Toll&like receptor agonists synergistically increase production of inflammatory cytokines in human neonatal dendritic cells. Hum Immunol. 68(10): 813—822. http://dx.doi.org/10.1016/j.humimm.2007.08.001; PMid:17961769

Levy O. 2005. Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists. Endotoxin Res. 11(2): 113—116. http://dx.doi.org/10.1177/09680519050110020701; http://dx.doi.org/10.1179/096805105X37376; PMid:15949138

Wang LW, Chang YC, Lin CY et al. 2010. Low-dose Lipopolysaccharide Selectively Sensitizes Hypoxic-Ischemia White Matter Injury in the Immature Brain. Pediatr Res. 68(1): 41—47. http://dx.doi.org/10.1203/PDR.0b013e3181df5f6b; PMid:20351655 PMCid:PMC3608684

McAdams RM, Juul SE. 2012. The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury. Neurol Res Int. 56: 14—94. http://dx.doi.org/10.1155/2012/561494

Oliveira-Nascimento L, Massari P, Wetzler LM. 2012. The Role of TLR2 in Infection and Immunity. Front Immunol. 3: 79. http://dx.doi.org/10.3389/fimmu.2012.00079; PMid:22566960 PMCid:PMC3342043

Lisciandro JG, Prescott SL, Nadal-Sims MG et al. 2012. Ontogeny of Toll&like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants. PLoS One. 7(5): 367—393. http://dx.doi.org/10.1371/journal.pone.0036793; PMid:22649499 PMCid:PMC3359332

Corbett NP, Blimkie D, Ho KC et al. 2010. Ontogeny of Toll&like receptor mediated cytokine responses of human blood mononuclear cells. PLoS One. 5(11): 15—41. http://dx.doi.org/10.1371/journal.pone.0015041; PMid:21152080 PMCid:PMC2994830

Piccinini AM, Midwood KS. 2010. DAMPening Inflammation by Modulating TLR Signalling. Mediators Inflamm. 67: 23—95. http://dx.doi.org/10.1155/2010/672395

Reiman M. 2009. Antenatal inflammation and brain pathology in preterm infants. Medica-odontologica turun yliopisto university of Turku. 863: 216.

Salmeen KE, Jelin AC, Thiet MP. 2014. Perinatal neuroprotection. F1000 Prime Reports. 6: 6. http://dx.doi.org/10.12703/P6-6; PMid:24592318 PMCid:PMC3883423

Belderbos ME, van Bleek GM, Levy O et al. 2009. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. Clin Immunol. 133(2): 228—237. http://dx.doi.org/10.1016/j.clim.2009.07.003

Takeda K, Akira S. 2004. TLR signaling pathways. Seminars in Immunology. 16: 3—9. http://dx.doi.org/10.1016/j.smim.2003.10.003; PMid:14751757

Lafferty E, Qureshi ST, Schnare M et al. 2010. The role of toll-like receptors in acute and chronic lung inflammation. Journal of Inflammation. 7: 57. http://dx.doi.org/10.1186/1476-9255-7-57; PMid:21108806 PMCid:PMC3003652

Yunanto A, Andayani P, Triyawanti E et al. 2012. Toll-like Receptor 2, Toll-like Receptor 4 Expression and Phagocytic Activity of Neutrophil in Saliva of New Born Babies With Sepsis Risk. An Early Detection Of Neonatal Sepsis. Journal of Dental and Medical Sciences (JDMS). 1(6): 17—20. http://dx.doi.org/10.9790/0853-0161720

Levy O, Suter EE, Miller RL et al. 2006. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Blood. 108(4): 1284—1290. http://dx.doi.org/10.1182/blood-2005-12-4821; PMid:16638933 PMCid:PMC1895876

Walker WE, Goldstein DR. 2013. Neonatal B Cells Suppress Innate Toll-Like Receptor Immune Responses and Modulate Alloimmunity. The Journal of Immunology. 57(8): 412—418.

Xu D, Liu H, Komai-Koma M. 2004. Direct and Indirect Role of Toll-Like Receptors in T Cell Mediated Immunity. Cellular & Molecular Immunology. 239: 645.

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Раздел

Актуальные вопросы перинатологии и неонатологии